Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited
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چکیده
منابع مشابه
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
The sequential enzymatic actions of beta-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the gamma-secretase complex liberate beta-amyloid (Abeta) peptides from larger integral membrane proteins, termed beta-amyloid precursor proteins (APPs). Relatively little is known about the normal function(s) of APP or the neuronal compartment(s) in which APP undergoes proteolytic pr...
متن کاملNeurobiology of Disease Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited
Orly Lazarov,1* Gerardo A. Morfini,2* Edward B. Lee,3 Mohamed H. Farah,4 Anita Szodorai,5 Scott R. DeBoer,2 Vassilis E. Koliatsos,4 Stefan Kins,5 Virginia M.-Y. Lee,3 Philip C. Wong,4 Donald L. Price,4 Scott T. Brady,2 and Sangram S. Sisodia1 1Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, 2Department of Anatomy and Cell Biology, Un...
متن کاملAmyloid precursor protein and axonal transport
........................................................................................... xv Chapter I – Amyloid precursor protein and its relationship to axonal transport . 1 Chapter II – Mutations at the β-secretase cleavage site of APP mediates its axonal transport ................................................................................... 10 Abstract .................................
متن کاملAxonal Transport of Amyloid Precursor Protein Is Mediated by Direct Binding to the Kinesin Light Chain Subunit of Kinesin-I
We analyzed the mechanism of axonal transport of the amyloid precursor protein (APP), which plays a major role in the development of Alzheimer's disease. Coimmunoprecipitation, sucrose gradient, and direct in vitro binding demonstrated that APP forms a complex with the microtubule motor, conventional kinesin (kinesin-I), by binding directly to the TPR domain of the kinesin light chain (KLC) sub...
متن کاملSubpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.
Intracellular transport of vesicles and organelles along microtubules is powered by kinesin and cytoplasmic dynein molecular motors. Both motors can attach to the same cargo and thus must be coordinated to ensure proper distribution of intracellular materials. Although a number of hypotheses have been proposed to explain how these motors are coordinated, considerable uncertainty remains, in par...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3089-04.2005